Fig. 4.
Functional FVIII expression in FVIIIKO-SCID mice following transient macrophage depletion.
Experimental mice were injected with clodronate liposomes (black lines) 1 day before injection with Ad-AAT-cFVIII at different doses: 108 (A), 5 × 107 (B), 107 (C), and 5 × 106 IU (D). Littermates were injected with PBS-containing liposomes as controls (gray lines). The detection limit of the assay corresponds to 30 mU/mL and was indicated on the graph by a dotted line.
