Schematic of gene therapy competitive repopulation experiments.

Donor BM cells from Fancc^−/−mice were transduced with either a retrovirus containing a reporter gene (MSCV-EGFP or MSCVpac) or a retrovirus encoding rFancc (MSCV-Fancc or MFG-FAC). WT donor cells were transduced with a retrovirus containing a reporter gene only (MSCV-EGFP or MSCVpac). Each respective donor cell population was cotransplanted into 5-8 lethally irradiated recipient mice with competitor cells from B6.BoyJ mice that were genetically identical to C57Bl/6J mice with the exception of distinct CD45 isoantigen expression.