LPS induction of inflammatory mediators in Egr-1^+/+ and Egr-1^−/− mice.

Egr-1^+/+ and Egr-1^−/− mice (5 or 6 per group) were injected intraperitoneally with LPS (12 mg/kg) and serial blood samples were collected at various times. Levels of TNFα (top), IL-6 (middle), and MCP-1 (bottom) were determined by ELISA in Egr-1^+/+ (▪) and Egr-1^−/− (■) mice. Data are shown as mean ± SE. The asterisk indicates that the change in MCP-1 is statistically significant (P < .05).