LPS induction of TF, PAI-1, and ICAM-1 mRNA expression in the kidneys of Egr-1^+/+ and Egr-1^−/− mice.

(A-F) Egr-1^+/+ and Egr-1^−/− mice (3 or 4 per group) were either untreated or injected with LPS for either 3 or 8 hours. TF, PAI-1, and ICAM-1 mRNA levels were measured by Northern blotting. Normalized levels of the various mRNAs are shown (mean ± SD). TF mRNA levels are expressed as fold induction, whereas PAI-1 and ICAM-1 mRNA levels are expressed as a percentage of the LPS-induced Egr-1^+/+ levels because of the absence of detectable expression in untreated mice. The asterisks indicate decreases that were statistically significant (P < .05).