BCR-ABL suppresses programmed cell death in a cell autonomous manner.

Percent apoptotic progenitors were analyzed as in Figure 3. To determine BCR-ABL cell autonomous versus noncell autonomous effects, the percent of apoptotic progenitors was analyzed within a culture containing both BCR-ABL–expressing and control cells by gating on EGFP⁺ and EGFP⁻ cells, respectively. A representative result of an experiment done in triplicate cultures is shown. Similar results were obtained in 3 independent experiments done in triplicate cultures.