BCR-ABL tyrosine kinase activity is required to suppress apoptosis in hematopoietic progenitors.

Percent apoptotic progenitors were analyzed by annexin V binding with progenitors already progressed to the stage of membrane permeability excluded by 7-AAD intercalation into DNA. Shown are representative results of an experiment done in triplicate cultures. Similar results were obtained in another independent experiment done in triplicate cultures.