Fig. 2.
Adenosine dose-dependently reduces IL-12 and TNF-α secretion, whereas it augments IL-10 release from mDCs.
DCs were treated with 3 μg/mL LPS in the presence of the indicated concentration of adenosine for 48 hours. Supernatants were harvested and the different cytokines were evaluated by ELISA. The results are expressed as mean pg/mL ± SEM (n = 3). P < .05 between LPS- and LPS + adenosine–treated DCs at concentrations of adenosine more than 10−6 M. Results are representative of 3 different experiments.
