GILZ inhibits chemokine production.

THP-1 cells were transfected with either a control plasmid or GILZ-pcDNA3 (GILZ). (A) RANTES and (B) MIP-1α concentrations in the supernatants. (C) RT-PCR experiments for GILZ, RANTES, and β-actin. The results are presented as means ± SEMs of 3 experiments, with 100% corresponding to unstimulated control cells. The concentrations (means ± SEMs) of RANTES and MIP-1α in these control cells were 1130 ± 768 pg/mL and 5172 ± 1452 pg/mL, respectively.