Fig. 11.
Fig. 11. Model of ELL protein-protein interactions with EAF1 and EAF2. / (A) EAF1 and EAF2 bind to the amino-terminus of the wild-type ELL protein, but only EAF1 binds to the carboxy-terminus of ELL. (B) The MLL-ELL fusion protein disrupts the amino-terminal protein-protein interaction domain of ELL but retains the carboxy-terminal EAF1 interaction domain.

Model of ELL protein-protein interactions with EAF1 and EAF2.

(A) EAF1 and EAF2 bind to the amino-terminus of the wild-type ELL protein, but only EAF1 binds to the carboxy-terminus of ELL. (B) The MLL-ELL fusion protein disrupts the amino-terminal protein-protein interaction domain of ELL but retains the carboxy-terminal EAF1 interaction domain.

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