Representative inflammatory responses to the allogeneic combination vaccine in punch biopsy specimens from the injection site.

(A) Mild perivascular lymphocytic inflammation in first sample (patient 13; hematoxylin and eosin (H&E) stain; original magnification, × 20). (B) Moderate perivascular lymphocytic and eosinophilic inflammation in first sample (patient 14; H&E stain; original magnification, × 20). (C) Severe perivascular lymphocytic inflammation in first sample (patient 4; H&E stain; original magnification, × 20). (D) Severe eosinophilic panniculitis in first sample (patient 14; H&E stain; original magnification, × 20). (E) Moderate infiltration of CD4⁺ lymphocytes in first sample (patient 1; CD45RO/OPD4 stain; original magnification, × 40). (F) Abundant perivascular CD8⁺ lymphocytes (patient 19; CD45RO/C8/144B stain; original magnification, × 40). (G) Retention of epidermal CD1a⁺ and rare dermal perivascular Langerhans cells (patient 20; O10 stain; original magnification, × 20). (H) Control tissue from healthy volunteer (O10 stain; original magnification, × 20).