Fig. 6.
Effect of a single dose of liposomal clodronate on clearance of opsonized RBCs.
A single dose of liposomal clodronate affects clearance of opsonized RBCs for 1 to 2 weeks. Mice were injected at the indicated times with either PBS or clodronate liposomes. RBCs were labeled with CFSE and opsonized with anti-RBC antibody in vitro. Control mice received an identical number of nonopsonized RBCs (5 × 108). Persistence of labeled RBCs was assessed by tail bleeding 4 hours later. Data are expressed as a percentage of circulating RBCs which were CFSE+ (± standard error). Data presented are from 1 representative experiment out of 2.
