Pulmonary targeting of ¹²⁵I-tPA conjugated with anti-ICAM in rats.

Biodistribution of ¹²⁵I-tPA conjugated to anti-ICAM IgG (▧) or control IgG (▪) 1 hour after intravenous injection in anesthetized rats. The data are shown as means ± SEM, n = 4. (A) Absolute values of the uptake in organs expressed as percent of injected dose per gram. (B) Immunospecificity index (ISI_%ID/g), calculated as ratio of anti-ICAM to IgG %ID/g. (C) Localization ratio (LR) calculated as ratio of %ID/g in an organ to that in blood. (D) ISI_LR calculated as ratio of anti-ICAM LR to IgG LR.