Fig. 2.
Fig. 2. CCR10 expression by peripheral blood memory TH subsets defined by memory markers and tissue-specific adhesion molecules. / (A) Cytometry plots showing gated populations from 5-color experiment analyzed in panel B. Left plot: CD45RA versus CD4 (on lymphocyte scatter gate) shows gating of naive TH(CD4+/CD45RA+) and memory TH(CD4+/CD45RA−). Right plot: expression of the adhesion molecules CLA and β7-integrin by memory THcells, showing cutaneous (CLA+/β7−), intestinal (CLA−/β7+), and undefined (CLA−/β7−). (B) CCR10 expression by each of the populations defined in A on a representative healthy blood donor. CCR10 staining (black line) overlaid on isotype-matched control staining (gray line). (C) Cytometry plots showing CLA versus CCR10 (left plot) or CLA versus CCR4 (right plot) in the memory TH lymphocyte gate for a representative healthy donor.

CCR10 expression by peripheral blood memory TH subsets defined by memory markers and tissue-specific adhesion molecules.

(A) Cytometry plots showing gated populations from 5-color experiment analyzed in panel B. Left plot: CD45RA versus CD4 (on lymphocyte scatter gate) shows gating of naive TH(CD4+/CD45RA+) and memory TH(CD4+/CD45RA−). Right plot: expression of the adhesion molecules CLA and β7-integrin by memory THcells, showing cutaneous (CLA+/β7−), intestinal (CLA−/β7+), and undefined (CLA−/β7−). (B) CCR10 expression by each of the populations defined in A on a representative healthy blood donor. CCR10 staining (black line) overlaid on isotype-matched control staining (gray line). (C) Cytometry plots showing CLA versus CCR10 (left plot) or CLA versus CCR4 (right plot) in the memory TH lymphocyte gate for a representative healthy donor.

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