Fig. 3.
Shear dependency of thrombus generation on a collagen surface in healthy controls and a type 2A and 2B VWD patient.
Whole blood from a healthy control (control-2 in Table 2), a type 2A (2A-1 in Tables 1 and 2), and a type 2B (2B-3 in Tables 1 and 2) VWD patient was perfused for 7 minutes with various shear rates. Each data point represents the mean (± SD in the case of a healthy control) surface coverage value in 5 areas (211 × 317 μm each) randomly selected in each single perfusion. Thrombus generation in a type 2A patient was reduced at shear rates above 630 s−1 (top panel), whereas that in a type 2B patient was reduced at a shear rate above 2040 s−1 (bottom panel).
