American Society of Hematology

Fig. 7.

$Fig. 7. Schematic of network-linked plus mobile CD47 molecules as they might function in signaling red cell “self” to macrophages.7. / Not shown are the many Rh proteins (and other components), so that the picture is most relevant perhaps to Rhnull red cells. The network-linked CD47 ensures a uniform, if sparse, distribution of this putative “marker of self,” while the mobile fraction of CD47 allows for affinity-driven clustering that reinforces the signal to SIRP-α on the macrophage.$

Schematic of network-linked plus mobile CD47 molecules as they might function in signaling red cell “self” to macrophages.7

Not shown are the many Rh proteins (and other components), so that the picture is most relevant perhaps to Rh_null red cells. The network-linked CD47 ensures a uniform, if sparse, distribution of this putative “marker of self,” while the mobile fraction of CD47 allows for affinity-driven clustering that reinforces the signal to SIRP-α on the macrophage.

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