Box charts of expression profiles of a panel of proliferation genes and XBP1 show similarities between tonsil BCs and MM4.
(A) The 7 tonsil BC (TBC), 11 tonsil PC (TPC), 31 bone marrow PC (BPC), 20 MM1, 21 MM2, 15 MM3, and 18 MM4 samples are distributed along the x axis and the natural log-transformed average difference call is plotted on the y axis. The top, bottom, and middle lines of each box correspond to the 75th percentile (top quartile), 25th percentile (bottom quartile), and 50th percentile (median) of the natural log-transformed average difference call for each gene, respectively. The whiskers extend from the 10th percentile (bottom decile) and top 90th percentile (top decile). The Kruskal-Wallis test for differences in expression of each gene across the groups are: EZH2,P = 7.61 × 10−11; KNSL1,P = 3.21 × 10−8; PRKDC,P = 2.86 × 10−11; SNRPC,P = 5.44 × 10−12; CCNB1,P = 2.54 × 10−8; CKS2,P = 9.49 × 10−11; CKS1,P = 5.86 × 10−9; PRIM1,P = 4.25 × 10−5. Note the similarity in expression of each gene in TBC and MM4. (B) Box chart ofXBP1. Note that all MM subgroups have lower median expression levels than BPCs and that MM4 has the lowest level of XBP1 in the MM subgroups. Lack of expression of XBP1 in MM4 may account for the relationship between MM4 and TBCs.
