A 2-dimensional hierarchical cluster analysis of experimental expression profiles and gene behavior of (A) vEDGs, (B) v1LDGs, and (C) v2LDGs.

Genes (HUGO-approved gene symbols, right side) are plotted along the vertical axis and experimental samples are plotted along the top horizontal axis by their similarity. A cluster-ordered data table was used to analyze 7 tonsil BC samples (red vertical bars), 7 tonsil PC samples (blue vertical bars), 7 bone marrow PC samples (yellow vertical bars), and 74 newly diagnosed MM cases. The nomenclature for the 74 MM samples is as indicated in Zhan et al.42 The normal cell-defined cluster for tonsil BCs (horizontal red bar), tonsil PCs (horizontal blue bar), and bone marrow PCs (horizontal yellow bar) are indicated. The clustering is presented graphically as a colored image. Along the vertical axis, the analyzed genes are arranged as ordered by the clustering algorithm. The genes with the most similar patterns of expression are adjacent to each other. Experimental samples are arranged the same way along the horizontal axis; those with the most similar patterns of expression across all genes are adjacent to each other. Sample groupings can be further described by following the solid lines (branches) that connect the individual components with the larger groups. The color of each cell in the tabular image represents the expression level of each gene, with red representing an expression greater than the mean, green representing an expression less than the mean, and the deeper color intensity representing a greater magnitude of deviation from the mean.