Pulmonary thromboembolism.

(A) Increased lethal thrombosis in transgenic mice after the intravenous injection of collagen and epinephrine and protection against thrombosis by the inhibition of ERK2. Survival in WT and TG mice is shown as a percentage of animals treated (*P = .017 vs WT; ^#P = .017 vs TG). (B) Antithrombotic protection after the inhibition of ERK2 in WT mice by the preinjection of U0126 (200 μg/kg) versus control (*P = .0187).