Increased NO (as nitrite) production by activated

Fancc^−/− macrophages.Supernatants from the peritoneal macrophages used in iNOS expression studies (Figure 5) were harvested for nitrite quantitation. There was a significant increase in nitrite levels in the supernatants ofFancc^−/− cells (at 8 hours) when macrophages were stimulated with IFNγ plus LPS or with IFNγ alone (although the latter did not reach significance). *P < .05.