Fancc^−/− BM progenitors demonstrate increased sensitivity to NO-generating compounds.

(A) Committed progenitor cell growth in the presence of increasing concentrations of the NO donor SNAP; 100% represents 89.5 total colonies (control) and 70.5 total colonies (Fancc^−/−). (B) Growth of committed progenitor cells in the presence of increasing concentrations of DETA/NO; 100% represents 104.5 total colonies (control) and 82.5 total colonies (Fancc^−/−). Percentage maximal colony formation was determined by dividing the number of colonies scored at a given concentration of NO donor by the number of colonies scored in the absence of the NO donor. n = 3 or 4 mice per genotype. *P ≤ .05; **P < .005.