Summary of 30 independent killing experiments for 15 different sera.
The ratio, the number of live Raji cells in NHS alone divided by the number of live cells for the treatment condition in NHS (RTX ± mAb 3E7), is displayed for individual NHSs at 3 different times. The means of the determinations are marked by horizontal dashes; the differences between RTX + mAb 3E7 vs RTX alone were statistically significant (P < 10−3) at all 3 times. The percentages of dead cells at 1 hour, 24 hours, and 48 hours for serum, serum + RTX, or serum + RTX + mAb 3E7 were as follows: 1 hour, 20 ± 10, 41 ± 12, 74 ± 11; 24 hours, 21 ± 14, 82 ± 12, 91 ± 7; 48 hours, 16 ± 11, 88 ± 9, 94 ± 5. For a given time the differences between the treatments were highly significant. In all cases P < 10−3 except for 48 hours, serum + RTX vs serum + RTX + mAb 3E7,P = 3 × 10−3.
