Compromised MK-vascular sinus interactions in TSP2-null marrow.

Representative TEM images of (A) wild-type and (B) TSP2-null (KO) marrow demonstrate the association between MKs and the sinusoidal endothelium. A TSP2-null MK displaying a lack of close continuous association with the subendothelium is shown in panel B. Sinusoidal lumen (L) and endothelium (arrows) are marked. Bar represents 0.5 μm.