Fig. 2.
Fig. 2. Schematic diagram showing the groups of molecules involved in the PI3Kγ-dependent and -independent signaling of F-actin polymerization during pseudopod extension. / The PI3Kγ-dependent F-actin polymerization is dependent also on PKCζ and Akt/PKB, while the PI3Kγ-independent F-actin polymerization is dependent on RhoA, ROCK, Src family tyrosine kinases, NADPH, and cAMP.

Schematic diagram showing the groups of molecules involved in the PI3Kγ-dependent and -independent signaling of F-actin polymerization during pseudopod extension.

The PI3Kγ-dependent F-actin polymerization is dependent also on PKCζ and Akt/PKB, while the PI3Kγ-independent F-actin polymerization is dependent on RhoA, ROCK, Src family tyrosine kinases, NADPH, and cAMP.

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