Summary of the AML1 point mutations identified in this study.

Horizontal bars diagrammatically show AML1 (453 aa) including the Runt domain (50-177; shaded boxes). The numbers in the left-hand column indicate the case numbers (1-13) described in Tables 2, 3, and 4. The regions where the point mutations are mapped in the runt domain are described in the right-hand column. Mutant numbers are used in the next figures.