Fig. 6.
Fig. 6. Effects of pCMBS on 10 μM ADP-induced adenylyl cyclase inhibition in CHO-K1 cells stably expressing human platelet P2Y12 wild type and mutants. / Cells expressing the wild-type or mutant P2Y12 receptors were pretreated with pCMBS for 10 minutes at 37°C before the addition of 20 μM forskolin. Data were normalized to the value obtained with forskolin alone (mean, ± SE. *P > .05, ***P < .001 compared with forskolin 20 μM + ADP 10 μM by t test).

Effects of pCMBS on 10 μM ADP-induced adenylyl cyclase inhibition in CHO-K1 cells stably expressing human platelet P2Y12 wild type and mutants.

Cells expressing the wild-type or mutant P2Y12 receptors were pretreated with pCMBS for 10 minutes at 37°C before the addition of 20 μM forskolin. Data were normalized to the value obtained with forskolin alone (mean, ± SE. *P > .05, ***P < .001 compared with forskolin 20 μM + ADP 10 μM by t test).

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