Fig. 4.
Fig. 4. Effect of BzATP on the wild-type and mutant P2Y12 receptors. / BzATP antagonizes 1 μM ADP-induced inhibition of adenylyl cyclase in CHO-K1 cells stably expressing either P2Y12WT, P2Y12Cys17Ser, P2Y12Cys270Ser, or P2Y12Cys17Ser/Cys270Ser stimulated with 20 μM forskolin. Data were normalized to the maximal response obtained with antagonist (mean ± SE, n = 3).

Effect of BzATP on the wild-type and mutant P2Y12 receptors.

BzATP antagonizes 1 μM ADP-induced inhibition of adenylyl cyclase in CHO-K1 cells stably expressing either P2Y12WT, P2Y12Cys17Ser, P2Y12Cys270Ser, or P2Y12Cys17Ser/Cys270Ser stimulated with 20 μM forskolin. Data were normalized to the maximal response obtained with antagonist (mean ± SE, n = 3).

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