Identification of genes specifically expressed in PEL by supervised pattern discovery analysis.

Gene expression profiles of 9 PEL cases were compared with those generated from normal (GC, naive [N], and memory [M]) B cell subpopulations, 16 AIDS-NHL (5 centroblastic [Cb], 4 immunoblastic [Ib], and 7 BL [Burkitt-like]), 31 DLBCL, 6 BL, 6 FL, and 20 B-CLL cases by supervised analysis using Genes@Work. Matrix and gene ranking are as in Figure 2. The support value for supervised analysis was chosen as n = n₀ − 1, where n₀ is the number of cells in the phenotype set (PEL), allowing for one unclustered sample per pattern in the phenotype set. Gene names are indicated; for GenBank accession numbers and Affymetrix codes, go to the Blood website and see the Supplementary Data Set link at the top of the online article. Genes whose expression was verified by immunostainings are indicated in red text; genes otherwise mentioned, in blue text.