CD437- and MM002-mediated apoptosis in WSU-CLL and ALL-REH cells.

Cells were seeded, treated as described in Figure 2 legend, and harvested at various times. Apoptotic cells were assessed by means of acridine orange staining as described in “Materials and methods.” The percentage of apoptotic ALL-REH (panel A) and WSU-CLL (panel B) cells following exposure to increasing concentrations of CD437 over time and ALL-REH (panel C) and WSU-CLL (panel D) cells following exposure to increasing concentrations of MM002 for 48 hours.