p15 methylation changes in MDS during treatment with decitabine.

p15 methylation (averaged and given as percentage as described in legend to Figure 1) was plotted before and after treatment with decitabine, as well as at relapse for some patients. Results of treatment courses are plotted separately for 12 patients with initialp15 methylation of more than 15% (A). Methylation as determined after ■, 1 course of decitabine; ▴, 2 courses of decitabine; ▪, 3 courses of decitabine; ●, 4 to 6 courses of decitabine (where possible at evaluation of the final course).