Fig. 1.
FA lentiviral vectors.
(A) Schematic representation of the FANCA and FANCC lentivectors used in this study. (B-C) MMC resistance assays performed on lentivector-corrected FANCA−/−andFANCC−/−human lymphoblastoid cells, respectively. AG09391 is a normal lymphoblastoid cell line. Values were measured in quadruplicate and corrected for background cell death in the absence of MMC. (D) Lentiviral-mediated rescue of the MMC-induced G2 block in FA cell lines. All values are the results of quadruplicate determination (mean ± SD).
