Spleen but not thymus cellularity in mice injected with recombinant hMOR/CHO cells is reduced compared with that in mice injected with CHO cells.

Mice injected with recombinant hMOR/CHO cells in which splenocytes were not sensitized to Fas-mediated apoptosis were excluded from the analysis. Panel A shows results when spleen cells from BALB/c mice injected with either PBS (n = 6; ○), CHO cells (n = 7; ▵), or recombinant hMOR/CHO cells (n = 4; ■) were enumerated by using trypan blue dye exclusion. Panel B shows the relative distribution of B lymphocytes (■), CD4 (▨) and CD8 (░) T cells, and monocytes (▪) in the spleen. Panel C depicts enumeration of thymic cells for each group. In panels A and C, results are expressed as means ± SD. Statistical analysis was performed by using the Mann-Whitney U test.