CD45 is expressed on leukemic blasts and is hematopoiesis specific.

(A) FACS analysis showing surface CD45 expression in PBMCs from 5 healthy controls compared with 5 patients with CML and BMMCs from 5 patients with AML or ALL. Each sample was stained with isotype control (dotted lines) and anti-CD45 (solid lines) antibodies, and the corresponding histograms are shown. (B) Northern blot analysis of CD45 RNA expression in various tissues.