Immunohistologic analysis of the expression of CD45Ra and CD45Ro in healthy skin and autoimmune skin disease.

(A) CD45Ra is poorly expressed in cells of healthy skin. CD45Ra is also poorly expressed in rare lymphocytes in skin samples from patients with T-cell autoimmune diseases: atopic dermatitis (B), lichen planus (C), and graft-versus-host disease (D). However, most of the skin-infiltrating lymphocytes in both healthy and diseased skin are CD45Ra⁺. (E) CD45Ro is significantly expressed in samples of healthy skin. Also, CD45Ro is highly expressed in skin samples from patients with T-cell autoimmune diseases: atopic dermatitis (F), lichen planus (G), and GVHD (H). The same 3 distinct patient skin samples were tested for each disease, and the same 3 for healthy skin as in the other figures. There was no difference between the samples displayed here and those not shown. All slides were photographed at × 50 original magnification.