Granzyme M (GM) expression in T-cell and NK-cell lymphomas.

(A) Nasal NK/T-cell lymphoma (nasal biopsy) with exuberant apoptotic necrosis. Apoptotic and viable tumor cells are strongly GM⁺. (B) Hepatosplenic γδ T-cell lymphoma (splenectomy specimen). Cordal and intrasinusoidal lymphomatous cells show intense GM positivity. (C) Intestinal T-cell lymphoma with medium-sized cells (resection specimen). Lymphoma cells reveal GM expression in the Golgi region. (D) Peripheral T-cell lymphoma of unspecified subtype (lymph node biopsy). There is an infiltrate predominantly composed of medium-sized cells with strong GM positivity in most cells.