Functional regions and genomic structure of Pax5.

(A) Locations of the paired domain (a 128 amino acid DNA-binding domain), an octapeptide homology region of unknown function, a partial homeodomain region, and a transactivating domain are indicated. The transactivating domain of Pax5 consists of an activator domain that is negatively regulated by a repressor domain. An alternative start site for Pax5 is indicated by the arrow. (B) An exon/intron map for the human Pax5 gene, which is located in chromosomal region 9p13. Exon sizes vary from 45 to 198 base pairs. The diagram is based on data from Celera Discovery System and Celera Genomics' associated databases and from accession no. AP002388, clone RP-11 675M6, sequenced by RIKEN Genomic Sciences Center.