TR6-Fc strongly augments lymphokine production by anti-CD3–stimulated spleen cells.

Mouse total spleen cells were stimulated with solid-phase anti-CD3 and TR6-Fc. The culture conditions were the same as described in Figure 1. The culture supernatants were harvested at 48 hours after the initiation of the culture and were tested for lymphokines with ELISA. Samples were studied in duplicate, and the means ± SD of lymphokine levels are shown. The experiments were conducted at least twice with similar results. A representative set of data is shown.