Anti-CD40L mAb alone or in combination with (A) sirolimus or (B) CsA results in long-term multilineage engraftment.

Mice from Table 1 were phenotyped at 3.5 months after BMT for donor-host origin of CD4⁺ and CD8⁺ T cells, CD19⁺ B cells and MAC-1⁺ myeloid cells. On the y-axis are shown the host and donor proportions of each of the lineages. The solid part of the bar indicates the proportion of each lineage that is of host origin; the striped part of the bar indicates the proportion of each lineage that is of donor origin. Irrelevant hIgG-treated mice had no detectable donor chimerism and thus are composed entirely of host-type cells. * Indicates P < .05 compared with donor proportion in mice receiving anti-CD40L mAb as a single agent.