Western blot analysis of molecules consisting of DISC in Ph1-positive leukemia cell lines.

Lysates from 12 Ph1-positive leukemia cell lines were analyzed by Western blot using antibodies against c-ABL kinase domain, FADD, caspase-8, and FLIP as described in “Materials and methods.” Small arrows and arrowheads indicate BCR-ABL proteins (p210, p203, and p190) and c-ABL protein, respectively, in panel A. Large arrows indicate FADD in panel B, caspase-8 in panel C, and FLIP in panel D.