Autoantigen-specific inhibition by RhD peptides that induce IL-10.

RhD peptides that elicit IL-10 responses by PBMCs from AIHA patients were added to respective PBMC cultures that had been stimulated to proliferate by purified RhD protein or by the unrelated recall antigen PPD. The percentage inhibition of proliferation is shown in 2 representative experiments using samples from AIHA patients 1 (A) and 2 (B). Similar results were obtained in a total of 8 experiments, using samples from 3 patients and testing at least 2 IL-10–inducing peptides on each occasion.