In vivo selection in the peripheral blood in response to CID, depicted as relative (A-C) and absolute (D-F) changes in GFP-positive cells over time.

CD34-selected marrow cells were transduced with the F36Vmpl^GFP vector and infused into the lethally irradiated autologous recipient as described.26 AP20187 administration for 30 consecutive days (indicated by the black rectangles) was begun in weeks 13 and 28 following the infusion of transduced cells, and the percentage of GFP-expressing cells was monitored by flow cytometry. Absolute cell numbers of GFP-positive red cells (D), white cells (E), and platelets (F) are expressed as 10⁻³ cells/μL blood. In panel D, for technical reasons, some data points are missing before, during, and after the first treatment cycle.