Cell cycling phenotypes and genetic analysis of C57BL/6 × B6D2F1 backcross mice.

(A) The percent progenitors in S phase for 60 N2 animals is depicted. Animals carrying 2 B alleles at D11Mit178 are indicated by ▪, whereas the ■ show heterozygous mice carrying 1 B and 1 D allele. (B) Interval mapping analysis of the N2 generation. The horizontal line indicates the statistical threshold for highly significant linkage, obtained by performing a permutation test with 2000 permutations at 1 cM intervals, on chromosome 11 only. (C) Interval mapping analysis of the N6 generation. (D) The percentage of CFU-GMs in S phase in wild-type B6 (n = 26), DBA (n = 29), and in congenic B6.DBA2^Scp2 animals (n = 17) is shown.