Fig. 4.
![Fig. 4. CML-DCs are defective in presentation at suboptimal dose of peptide. / DCs were generated from healthy individuals (○) and from CML patients (●): patient 1 (A-C) and patient 2 (D-F). Immature HLA-DR7–expressing DCs were pulsed overnight with 3 different doses of peptide HA307-319 (1 μg/mL [A,D]; 0.1 μg/mL [B,E]; 0.01 μg/mL [C,F]). Different numbers of irradiated and prepulsed DCs were cultured in the presence of HA307-319–specific T-cell clone (7P24). The data are expressed as counts per minute (cpm) ± standard deviations (SD). Data are representative of 5 experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/101/9/10.1182_blood-2002-06-1841/4/h80934217004.jpeg?Expires=1724260259&Signature=udd2ZNzQ2ag8eyzEmLmvW9AksxBV8vw-rm-aGKou2tVdNb1QEnubI~XGWP-~ilZHIbLj9O7Lfzy6wa92hFigsWfsRb~nMNvO6to70ob88qPrfYtooBjjr6~E9FM8-sT0~fpN2ye1fTk13p2f9H1nOPgV10mm3yo~jMFfrvBxp4Kh9slmiFRzCLFMOJgw1q1mMsPLY0loHPhvf7j76KeOCf64GrjYWTt1tVbnjRVtf5DQeke7G1kEw9Q1h9-gVoAmzSFazLQkej0hRvjzPwMNmBX8pSvIcqWJrWRfcidTbYSMGbOwTU~sh1HtEhJ4WheiXeG5QhPjpIZeWn5iI5I6rg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CML-DCs are defective in presentation at suboptimal dose of peptide.
DCs were generated from healthy individuals (○) and from CML patients (●): patient 1 (A-C) and patient 2 (D-F). Immature HLA-DR7–expressing DCs were pulsed overnight with 3 different doses of peptide HA307-319 (1 μg/mL [A,D]; 0.1 μg/mL [B,E]; 0.01 μg/mL [C,F]). Different numbers of irradiated and prepulsed DCs were cultured in the presence of HA307-319–specific T-cell clone (7P24). The data are expressed as counts per minute (cpm) ± standard deviations (SD). Data are representative of 5 experiments.
