Survival of mice against lethal infection withPseudomonas aeruginosa.

Groups of mice were challenged with P aeruginosa (D+7, 300 CFUs, intraperitoneally) following total body irradiation and reconstitution with 200 HSCs (gray filled circles) or with 200 HSCs plus 1 × 10⁴ CMP and 2 × 10⁴ GMP (black filled squares; P = .0002). Mice that succumbed to infection became moribund as early as 18 hours after infection. Animals that survived beyond D+10 remained healthy throughout the experimental period. Animals not undergoing transplantation that were not infected served as controls for the lethal irradiation dose (broken line). The arrow indicates day of challenge with P aeruginosa.