Plasma AMI pharmacokinetics following IVIG treatment.

Rats (3/group) were dosed intravenously with saline (●) or 2 g/kg (♦) IVIG, followed by AMI (8 mg/kg). AMI concentrations were determined via ELISA. Error bars represent the SD about the mean concentration at each time point. IVIG treatment significantly increased the clearance of AMI (P < .001), calculated from the concentration versus time profiles shown in this figure. The effects of IVIG on antibody pharmacokinetics are not specific for 7E3.