Constitutive secretion of MIP-1α and MIP-1β by MM cells.

MM cells were isolated from bone marrow MNCs of patients with MM who had no or a single radiographically demonstrated osteolytic lesion or 2 or more lesions. MIP-1α and MIP-1β levels in the culture supernatants of the cells were measured by enzyme-linked immunosorbent assay (ELISA) as described in “Materials and methods.”