Fig. 3.
![Fig. 3. SU11248 inhibits cellular proliferation and induces apoptosis. / (A) Cells were serum starved overnight and then cultured in the presence of SU11248 or vehicle control for 48 hours (with addition of FL for OC1-AML5 [FLT3-WT] cells). Proliferation was assessed in triplicate for each condition using the Alamar blue assay, and the mean ± SD is shown for each condition. (B,D) MV411 cells (FLT3-ITD) and (C,E) OC1-AML5 treated with SU11248, or vehicle control, in the presence of FL for OC1-AML5 cells only. Apoptosis was assessed after 24 hours of incubation by Western analysis for PARP cleavage (B-C) or caspase-3 (D-E). Similar results were obtained in at least 3 independent experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/101/9/10.1182_blood-2002-07-2307/4/h80934253003.jpeg?Expires=1724249318&Signature=U~6HUwkuZ-NKYAI-kRDl9-Mi29G1DpCnlk~uPGFK9sjrlnPcoXOJQ0htAOnVb45yKDgkm1nEY2pmooIybr--QfHpKW8UJve74KyLKLdNVjJauXxkqpEq2kZbH8cydZzTf~yH2BkM4cULxPP0cBytDOXy59yKPFPWXKPCwUvlvd8IgkPEiGAGn~20fKBlsi5pG0c5Lw-JABIdXtzK-m8dFAC3UT3SJV2GvEAGt~bfL6JWLByOtZcTxmAYhtmmGjI5KzRUvjeKrFVZSV8x4Rc2bdl3QD3MXX7Ag00LqGAEqFAfgwzctHHQloG4sMcuZvRdtInEF5ilqdeE~F4MzsnQvw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
SU11248 inhibits cellular proliferation and induces apoptosis.
(A) Cells were serum starved overnight and then cultured in the presence of SU11248 or vehicle control for 48 hours (with addition of FL for OC1-AML5 [FLT3-WT] cells). Proliferation was assessed in triplicate for each condition using the Alamar blue assay, and the mean ± SD is shown for each condition. (B,D) MV411 cells (FLT3-ITD) and (C,E) OC1-AML5 treated with SU11248, or vehicle control, in the presence of FL for OC1-AML5 cells only. Apoptosis was assessed after 24 hours of incubation by Western analysis for PARP cleavage (B-C) or caspase-3 (D-E). Similar results were obtained in at least 3 independent experiments.
