Selected novel genes identified from the myeloma library.

Proteins were aligned using multiple sequence alignment algorithm Clustal W 1.8 and shaded using Boxshade 3.21. (A) Sequence alignment of hypothetical protein MGC3178 (also called 58 kDa glucose-regulated protein) with putative disulfide isomerases from different species. The thioredoxin domains are underlined. The accession numbers used in the analysis are as follows: Acanthamoeba (AAC37215),Caenorhabditis elegans (P34329), Drosophila (AAK93133), and ERP72 (A23723). (B) A variant of Bim (Bam) specifically expressed in a multiple myeloma sample aligned with BimEL (AAC39593.1), an unnamed protein (CAC09660.1), and BimL (AAC40030.1). (C) Amino acid sequence alignment of a putative novel receptor with similarity to MMTV receptor-1 (AAF32283), MMTV receptor-2 (AAF32282), unknown protein MGC15887 (AAH09447), and clone 24574 (AF052151). (D) Protein sequence alignment of a novel SH2 domain containing adaptor with T-cell–specific adapter protein TSAd (AAF69027.1), an SH2 adaptor protein (AF051325.1), p56lck-associated adapter protein Lad (AAB58422.1), hypothetical protein FLJ14886 (AAH16826.1), and an unnamed protein (AK024799.1).