Intravenous ATO prolonged QTc and APD.

(A) Continuous ECG monitoring revealed progressive prolongation of QTc by intravenous ATO in a dose-dependent manner. *P < .05 versus control; #P < .01 versus control; +P < .001 versus control. (B) APD after 2-hour drug infusion. The prolongation was dose-dependent. *P < .05 versus control; #P < .01 versus control; +P < .001 versus control.