Alterations identified in PAX5alt and PAX5 P80R subtypes. PAX5alt: genetic alterations including gene rearrangements (PAX5r), sequence mutations (PAX5mut), and focal intragenic amplifications (PAX5amp) are shown in the heat map. PAX5 P80R: protein domain plot of PAX5 showing the 57 mutations detected in 44 patients in the PAX5 P80R subtype. CNA, copy number alteration; CN-LOH, copy-neutral loss of heterozygosity; hetero, heterozygous mutation; homo, homozygous mutation; NA, not available; NLS, nuclear localization signal; WT, wild type.