Antineoplastic drug sensitivity in cell lines.

(A) Mitoxantrone, (B) topotecan, and (C) idarubicin. ♦ indicates OCI-AML3; ■, clone 3.3;, clone 6.2. Clones were incubated with continuous drug exposure at the indicated concentrations for 96 hours, at which time cell viability was assessed using a modified MTT reagent. Results are expressed as percentage of cells viable relative to the initial number of cells. Error bars represent the SD from 6 replicates of each dose.